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Tolerability: Side effects are generally mild to moderate, predominantly gastrointestinal, and mirror the safety profile expected with injectable treatments

When to monitor and how For patients on FDA-approved GLP-1 drugs, reasonable monitoring approach: Document baseline BP before starting Home BP monitor for patients with baseline hypertension or on antihypertensives

Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats

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Notably, the MC4R agonist setmelanotide (IMCIVREE) was recently approved by the US FDA to manage BBS-associated weight gain and is under evaluation for additional therapeutic effects in BBS patients (45, 46)