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The procedure was as follows: [1] (square-cube law), [2] (square-cube law), [3] (from [1], after dividing both sides by A 1 ), [4] (from [3] , after taking the square root of both sides), [5] (from [2] , after dividing both sides by V 1 ), and [6] (after incorporating expression [4] into equation [5] )
Hence it stands to reason that there must be evidence of such stress pre-recruitment, or its confident expectation on the basis of numerous published reports - provided that ineligible patients are excluded and that patients do not change their lifestyles for the duration of a trial
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