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For example, specific GIPR variants may suggest a stronger biological response to tirzepatide's dual-agonist approach, while GLP1R variants inform GLP-1-only responsiveness

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Insulin and insulin secretagogues - Adding tirzepatide to insulin or insulin secretagogues (e.g., sulfonylureas, meglitinides) increases the risk of hypoglycemia

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Optometrists should advise their patients that although these medications are conclusively linked to an increased risk of NAION, the overall risk is still extremely low: only about 2.30 per 100,000 people are diagnosed with NAION each year