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High-dose oral therapy (10002000 micrograms daily) can effectively treat deficiency even in those with impaired intrinsic factor-mediated absorption, relying on passive diffusion

Options include higher dosing to finish faster, freezing portions (accepting some potency loss), or accepting the waste as acceptable cost of the protocol

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Pharmacol Res 105:9398 Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ, Seidah NG, Murphy RA (2001) Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor