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Unlike sedative medications that essentially force your brain into an unconscious state, DSIP appears to work by modulating the natural mechanisms that regulate sleep quality and depth

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The resulting decrease in thyroid hormones impacts cells throughout the body, causing symptoms such as: Fatigue Weight gain Headaches and migraines Thinning or dry hair, nails, and skin Feeling cold all the time Irregular periods Puffiness or fluid retention Fertility problems Slow digestion and constipation Brain fog Depression Aching muscles and joints Loss of muscle strength and tone These symptoms may be vague early on, but the inflammation can result in an enlarged thyroid (goiter) and thyroid nodules over time

PMID: 23603417 DOI: 10.1016/j.pbb.2013.04.005 Shytle RD et al (2002): Mecamylamine (Inversine): an old antihypertensive with new research directions

Fosgonimeton Phase 1 Trials M3 Biotechnology (later Athira Pharma) completes Phase 1 safety trials of fosgonimeton, a prodrug of Dihexa