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Combining all three targets allows for synergistic metabolic benefits , while GLP-1 and GIP help buffer the blood sugarraising effect of glucagon [7]
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Those with a T2DM diagnosis or prescriptions for first-line diabetes drugs such as metformin were placed in the T2DM group
Harmonic restraints of 50.0 kcal mol 1 2 were applied to the solutes, including the crystallographic ions, to allow solvent relaxation while preserving the maximum fidelity to the docking pose, and the Andersen temperature coupling scheme 81,82 was used to control and equalize the temperature
Authors' contributions GG carried out GP method optimization and evaluation of GP activity in pregnancy
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