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It has been reported that the intestinal environment (bacteria and viruses) changes even before the onset of type 1 diabetes mellitus (T1DM) and that there are bacteria that inhibit the onset of T1DM 3,4,5

The FDA-approved labeling for semaglutide, liraglutide, tirzepatide, and other GLP-1 medications does not list cortisol reduction as a mechanism of action or therapeutic effect

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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females