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Neutrophils promote Alzheimers disease-like pathology and cognitive decline via LFA-1 integrin
Betsholtz, Some studies suggest that the disrupted BBB after stroke may have detrimental effect on the cerebrum, which includes the loss of cerebral blood-pressure autoregulation (Sandoval and Witt, In the present study, mannitol was used to increase the BBB permeability, and a reversible global cerebral ischemic model of mice combined with confocal and two-photon microscopy was used to evaluate the effect of increased BBB permeability on both the microglial response and restoration of dendritic structures of layer 5 pyramidal neurons in somatosensory cortex
10.1007/s00210-024-03485-x 48 WellmanA
The most common causes include B12 supplementation (particularly injections), liver disease releasing stored B12, haematological disorders increasing B12-binding proteins, and chronic kidney disease reducing B12 excretion
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