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In low oxygen situations (hypoxia, ischaemia) lactate increases several-fold as its conversion from pyruvate in the lactate dehydrogenase reaction is essential to regenerate NADH needed to maintain glycolysis [59]
Role of magnesium in cardiovascular diseases
McKay NJ et al
Moreover, using probucol (500 mg/day, P.O for 6 months) for secondary prevention in patients with CHD lowered the incidence of the patients primary endpoint (cardiovascular disease death, hospitalization rate), which may be partly due to its strong antioxidant capacity [245]
Starting GLP-1 too early may increase nausea, vomiting, or surgical complications
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