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This phenomenon has been observed with other diabetes treatments as well
![what does a glp 1 agonist do Non-insulin injectable antidiabetic drugs - GLP-1 agonists and amylinomimetics glp-1_analogs [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/glp1.png?w=600&tok=baf39c)
Bioavailability is generally lower compared to injectables, meaning you might need consistent, long-term use to see results
![what does a glp 1 agonist do Non-insulin injectable antidiabetic drugs - GLP-1 agonists and amylinomimetics glp-1_analogs [TUSOM | Pharmwiki]](https://kajabi-storefronts-production.kajabi-cdn.com/kajabi-storefronts-production/file-uploads/blogs/2147576499/images/634765-0ff3-bd-7e8e-a3b4f0a84a1_15c47a89-dcd5-4de9-bd0a-84ef006e2dbc.jpg)
Novo Nordisk no longer races alone
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Retatrutide is a synthetic peptide based on a glucose-dependent insulinotropic polypeptide (GIP) backbone, but uniquely, it functions as a triple agonist
![what does a glp 1 agonist do Non-insulin injectable antidiabetic drugs - GLP-1 agonists and amylinomimetics glp-1_analogs [TUSOM | Pharmwiki]](https://s3.ap-southeast-2.amazonaws.com/nzdoctor.files/production/public/styles/cropped_image_16_7_/public/2025-10/Nutrition%20Figure%202_CR_NZD.jpg?itok=BvdIQ-RU)
A recent study (7) found that people taking GLP-1 medications frequently fall short of recommended daily intakes for several essential nutrients, including fibre, calcium, magnesium, potassium, iron, choline, and vitamins A, C, D, and E
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