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At low concentrations, C16-carnitine activates the Ca 2+ -ATPase of the cardiac SR, increases Ca 2+ binding, and promotes the binding of Na, K-ATPase to [ 3 H]ouabain, which may enhance myocardial Ca 2+ regulation
L.RossingP.ScottD.ShamkhalovaM
The potentiation of ligand activity by membrane association also suggests that natural secreted ligands may have an as-yet unidentified partner that provides a membrane anchor
The article calls for baseline liver and pancreatic labs before starting and reassessment every three to six months, with ongoing attention to liver function, lipase and blood glucose
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