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A lower ratio in people who use GLP-1 medications may point to a higher risk of developing NAION, which affects blood flow to the optic nerve
Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)
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It doesn't just improve blood flow
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