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Glutathione is involved in Phase II liver detoxification, playing a role in the conjugation and elimination of toxins
Expression of PKM2 in cancer has been suggested to enhance proliferative metabolism by causing a backflow of metabolites into anabolic pathways such as the serine biosynthesis pathway 8
If the DNA damage is too severe or there is a defect in the DNA repair pathway, DNA repair will ultimately fail 5-7
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