Depolarization of pericytes can also result from neuronal transmitters like NA, ATP, and Ang2 binding to their corresponding receptors on pericytes, as well as from astrocytic AA entering pericytes [102, 103]
We previously showed the presence of mitochondrial dysfunction as early as P15 in the motor cortex, but more precisely in the CSMN of TDP-43 A315T mice 17 , one of the best characterized mouse models of TDP-43 pathology 16,19,33,34
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Long-term oral glutathione supplementation was associated with increased body stores of glutathione evidence that the reduced form can be built up over months, not just topped up for a day
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