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In 1936, endocrinologist Hans Selye had published a landmark paper in Nature, describing how many different harms toxins, injury, and cold temperature can trigger the same biological stress response
Metabolism: clinical and experimental, 46(1), 8996
Elderly patients may be more sensitive to the medications effects and may require slower titration or lower maintenance doses, particularly if they have reduced renal function or are at higher risk for dehydration from gastrointestinal adverse effects
10.1038/nature11986 117 ThomasC.MackeyM
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