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For researchers and clinicians, this means making decisions based on incomplete information
That standard applies to investigational therapies too we dont prescribe what we cant verify is safe for your specific physiology
Published research has demonstrated that disrupted circadian signaling in aging is associated with increased cancer risk (DNA repair timing is compromised), metabolic dysfunction (insulin sensitivity follows a circadian pattern), impaired immune surveillance (immune cell activity peaks at specific circadian phases), and accelerated cardiovascular aging (blood pressure regulation is circadian-dependent)
Other GLP-1s like semiglutides (brand names Wegovy/Ozempic) : there is less concern about a direct drug-drug interaction
JCI Insight 8 , (2023)
