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Based on our data, we propose that T3 has a regulatory role in insulin-controlled glucose metabolism, and T3 exerts this function by increasing non-12-OH FXR-antagonistic BA levels via downregulating the expression of CYP8B1, which potentiates GLP-1 production via suppressing the intestinal FXR signaling
The study was conducted by Dr Marcel Muskiet of Leiden University Medical Center in the Netherlands, Professor David Cherney of the University Health Network and the University of Toronto in Canada and colleagues
The reconstituted peptide longevity guide provides detailed timelines for maintaining potency at different storage conditions
Concentrations can range from 1-5% in serums to 100% as a single face oil (how it's most traditionally used)
The dose is then slowly increased over several weeks or months in increments (e.g., to 0.5 mg, 1.0 mg, 1.7 mg), typically reaching a maintenance dose of 2.4 mg once weekly
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