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Naltrexone blocks that feedback loop, allowing the appetite-suppressing effect of bupropion to last longer and be more potent
Initiated in 2019, the study was halted early based on a recommendation from the Independent Data Monitoring Committee after a median follow-up of 3.4 years, as it met the pre-defined efficacy criteria
Earlier concerns regarding acute pancreatitis and pancreatic cancer have largely been alleviated by long-term randomized trials that have not confirmed a causal association, although reporting biases and diagnostic complexity remain considerations, and continued pharmacovigilance is recommended
Podolsky, M
