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On one hand, Nrf2 activators (such as dimethyl fumarate, sulforaphane, and other electrophilic small molecules) induce the expression of downstream antioxidant genes like HO-1, NQO1, and GCLC, enhancing GSH synthesis and ROS clearance capacity, thereby weakening lipid peroxidation driven by the Fenton reaction, stabilizing GPX4 and system Xc function, and potentially inhibiting ferroptosis (290)

Can PDA replace surgery or physical therapy

Although some progress has been made in the study of flavonoids in iron overload, research has mainly focused on in vitro studies and l sufficient in vivo and clinical evidence is lacking, which are important considerations in evidence-based medicine