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The dual GLP-1/GIP mechanism clearly outperformed single-agonist semaglutide
However, semaglutide also suppresses appetite, so some people take Rybelsus off-label for weight loss
These symptoms generally improve once the dose-escalation period ends
The NHS prescription charge applies (9.65 per item in England as of 2023/24, though prescriptions are free in Scotland, Wales, and Northern Ireland), but patients with diabetes or certain other conditions may be exempt
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