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The most important factor for safety is working with a qualified medical professional

That can be helpful for weight loss, but it can also make it harder to get enough of the nutrients your body needs

Semaglutide may calm brain inflammation, especially in the brains immune cells called microglia, and help protect the blood-brain barrier which acts like a security guard for the brain, Tousi said

Orlistat works in the gut to block fat absorption but may cause oily stools, gas, and urgency