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Adverse Reactions/Side Effects The following serious adverse reactions are described below or elsewhere in the prescribing information: Risk of Thyroid C-cell Tumors [see Warnings and Precautions (5.1)] Severe Gastrointestinal Adverse Reactions [see Warnings and Precautions (5.2)] Acute Kidney Injury Due to Volume Depletion [see Warnings and Precautions (5.3)] Acute Gallbladder Disease [see Warnings and Precautions (5.4)] Acute Pancreatitis [see Warnings and Precautions (5.5)] Hypersensitivity Reactions [see Warnings and Precautions (5.6)] Hypoglycemia [see Warnings and Precautions (5.7)] Diabetic Retinopathy Complications in Patients with Type 2 Diabetes Mellitus [see Warnings and Precautions (5.8)] Pulmonary Aspiration During General Anesthesia or Deep Sedation [see Warnings and Precautions (5.9)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

Hence, EBV UTPase may alter the synaptic structure and function in ME/CFS, as well as dysregulate neuronal communication, influencing cognitive processes
Joint and Bone Health Some research has looked at cartilage and bone healing in animal models of joint injury
However, since semaglutide is a relatively new medication, researchers are still studying how it affects the body over many years, including whether there are any rare side effects that only appear with very long-term use