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Beck DE, Sweeney WB, McCarter MD, et al
Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel , leading to relaxation of airway smooth muscle (ASM) cells
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[100] Men in both studies, on a diet devoid or nearly devoid of vitamin C, had blood levels of vitamin C too low to be accurately measured when they developed signs of scurvy, and in the Iowa study, at this time were estimated (by labeled vitamin C dilution) to have a body pool of less than 300 mg, with daily turnover of only 2.5 mg/day
Women consistently report this as the first noticeable effect, typically within 10 to 18 days of starting the protocol
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