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Notably, the acetylation-defective mutant p53 3 KR, which cannot induce cell-cycle arrest, senescence or apoptosis, fully retains the ability to suppress SLC7A11 and trigger ferroptosis under oxidative stress (Le et al., 2015)
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The most common side effects reported in clinical trials include mild nausea, reduced appetite, bloating, and occasional vomiting, particularly during the early weeks of treatment
The most common side effects include dryness, mild irritation, or increased sensitivity to sunlight
