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Reversal of adenine toxicity by pyrimidine mucleosides

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10.1007/s00394-011-0197-0 99 Rivillas-AcevedoL.Maciel-BarnL.GarcaJ

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J Invest Dermatol (1993) 101:648

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Meanwhile, hypoxia activates the HIF-1/PDK4 axis, which inhibits PDH activity and elevates mitochondrial membrane potential(MMP), suppressing the TCA cycle while enhancing glycolysis and lactate production, ultimately driving VSMC cell cycle progression and proliferation [86]

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