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Inhibitors with pyrrolidine/trifluorophenyl moieties as the S1-binding fragment similarly bind to the enzymes S 1 , S 2 , and S 2 extensive domains, whereas the binding mechanism of pyrimidine-2,4-dione analogs differs through additional interactions with the S 1 ' and S 2 ' pockets (Figure 2A)
Best practice is a 4-week rotation cycle
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