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Monosodium urate (MSU) crystals deposited in synovial tissue can interact with the innate immune system, triggering an inflammatory response that results in typical symptoms of gout, including pain, swelling, and redness [7]

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[10] [11] [12] In the TMD domain a fulcrum of polar residues regulates the biased signaling of the receptor [10] while the transmembrane helical boundaries [13] and extracellular surface are a trigger for biased agonism

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Clayton AH, Althof SE, Kingsberg S, et al