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22 It is important to note that maintenance of weight loss is an unmet need that should be taken into account during follow-up of MASLD patients

The worst-case scenario is not treating obesity at all and experiencing progressive metabolic deterioration, cardiovascular disease, diabetes, and reduced quality of life over decades

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Additional safety considerations include caution in patients with severe gastroparesis, and a potential risk of diabetic retinopathy complications with rapid glucose improvement, particularly with semaglutide