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A review of the pathophysiology of functional hypothalamic amenorrhoea in women subject to psychological stress, disordered eating, excessive exercise or a combination of these factors

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Mitochondrial dysfunction leading to oxidative stress also induces FGF21 expression in preclinical disease models (110), while levels of FGF21 are elevated in the circulation and skeletal muscle of patients with myopathies caused by mutations in components of the mitochondrial oxidative phosphorylation machinery (111)

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HPLC-purified to analytical-grade standards, it is suitable for controlled biochemical research and assay applications