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Deficiency of vitamin B12 may cause tiredness, weakness, constipation, loss of appetite, weight loss and megaloblastic anemia (a condition when red blood cells become larger in size than normal)

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Controlled environments reduce this risk

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Genetic Factors in Appetite and Body Composition DEREK MUNRO: Now, one of the things thats tough is its like, even though maybe that case study exists and theres people who just brute force willpower their way through it, some of those people otherwise might have genetically been able to tolerate, you know, the hunger signaling better than somebody else who literally cannot focus on work or anything when theyre that hungry