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Papaioannou A, Liakopoulou A, Papoulis D, Gianni E, Gkolfi P, Zygouri E
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16,17 In adipose tissue, specificity is governed by specificity protein 1 (Sp1) for basal transcription, while c-Jun N-terminal kinase (JNK) signalling enhances FGF21 production in obesity, and Rev-erb alpha modulates signalling through repression of beta-Klotho (-Klotho), the FGF21 coreceptor
It corresponds to the molecular formula C221H342N46O68 and a monomeric mass of approximately 4731 Da
We also found that neutrophil spEVs suppressed reactive oxygen species (ROS) production by neutrophils, delayed ROS production by monocytes, reduced IL-8 production by other neutrophils and monocytes, increased the viability of monocytes differentiating into macrophages, while increasing neutrophils TGF-beta production, all reflective of anti-inflammatory characteristics 6,11,12,13
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