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[14] [15] The relationship between diabetes and erectile function is multifactorial, involving vascular, neurological, hormonal, and psychological mechanisms that collectively impair the ability to achieve or maintain an erection sufficient for sexual activity

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The authors themselves described it as a small preliminary study.[15] A 2025 pilot report described intravenous administration to two healthy adults at doses up to 20 mg, with no measurable changes in cardiac, hepatic, renal or thyroid biomarkers and no reported adverse effects.[16] Two individuals cannot characterise uncommon reactions, immunogenicity, long-term toxicity, reproductive safety or oncological risk

It causes painful swelling, heaviness, sensitivity, and a frustrating resistance to diet and exercise