Pflgers Arch 372:2935 Trussell LO, Jackson MB (1987) Dependence of an adenosine activated potassium current on a GTP binding protein in mammalian central neurons
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Common side effects include nausea, vomiting, constipation, and appetite suppression, typically mild and transient
In contrast, in some situations, particularly when combined with high-dose ACEI, DPP-4i may exhibit hypertensive effects by stimulating sympathetic activity and alleviating the degradation of GLP-1 and substance P
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