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Leiderer, R
Most failed protocols collapse the loading phase into 35 days of high-dose injections, triggering intolerable side effects before meaningful melanogenesis occurs
Diabetes Care 39(Suppl 2):S165S171
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Often creates active metabolites Phase II metabolism: Conjugation, glucuronidation, acetylation etc Occurs in the liver and kidneys Involves other enzymes to CYP450 (various transferases) Often involves the addition of polar groups Often deactivates metabolites Excretion This involves the removal of the drug from the body
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