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IgG3 and IgG2 are notably transcytosed less efficiently than IgG1 and IgG4 [84], likely because of a missing glycine in the lower hinge of IgG2 [338] and an arginine instead of a histidine in amino acid position 435 in IgG3 [339, 340]
This calculator is suitable for UK TRT patients and follows internationally recognised dilution and dosing principles
In a word: Yes, for those with absorption issues
Block G, Jensen CD, Norkus EP, Hudes M, Crawford PB
That gap is worth planning around: the beyond-use window of a reconstituted solution (covered in the storage section) can be shorter than the drug supply lasts, especially for the 10 mg vial, so re-order and reconstitution-volume decisions should be made against the shorter of the two limits the stability window or the drug supply not just the drug supply alone
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