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18 The SYNERGY-NASH (A Study of Tirzepatide [LY3298176] in Participants With Nonalcoholic Steatohepatitis) trial, 19 a phase 2b dose-finding study, randomized 190 patients with biopsy-confirmed MASH and stage 2 or 3 fibrosis to receive weekly injections of the GLP-1 and GIP dual agonist tirzepatide 5 mg, 10 mg, or 15 mg or placebo for 52 weeks

First: the lipolytic effect in animal models (in rats and mice on a high-fat diet) did not translate to humans with stabilized obesity

Conclusion Retatrutide is a single peptide conjugated to a lipid diacid molecule

Blinding and allocation concealment are often inadequately reported, increasing the risk of bias

[135] found a reduced gastric emptying in PWS, though their ghrelin levels were remarkably higher, which may be related to altered ANS