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Without IF, vitamin B12 cannot be effectively absorbed from food

Vitamin B 12 deficiency Vitamin B 12 deficiency , also known as cobalamin deficiency , is the medical condition in which the blood and tissues have a lower than normal level of vitamin B 12

[7] In a 2026 neuropathic-pain study, photoaffinity-probe experiments identified LanCL1 as a binding target of LAT8881-derived probe material in nervous-system models, and LanCL1 knockdown blocked the reported LAT8881 activity in those models

See the AAAaAI review, a related PubMed case series and an FDA pharmacovigilance memo for more detail