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In subsequent studies: PIONEER-6 and ELIXA the primary endpoints (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, hospitalization for unstable angina) were not met in the GLP-1 RAs group, but a significant decrease in glycated hemoglobin was observed
Zhai Y, Li O, Qi R, Zhang H, Ji XK, Li H
Is Semaglutide Tested in Standard Blood Tests or Drug Screens
Nature medicine , 28 (10), 2083-2091
A patient on Wegovy 1.0 mg weekly might begin tirzepatide at 2.5 mg weekly rather than 1.0 mg, because tirzepatide's dual-receptor activation produces stronger metabolic signaling at lower nominal doses
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