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Constipation can occur as gastric emptying slows significantly

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(A 2022 clinical trial published in the New England Journal of Medicine found that roughly 80% of people taking Zepbound did.) Research and obesity medicine specialists have identified a few common patterns for when symptoms tend to flare up: Early on, especially during the first few weeks Within 48 hours of an injection After a dose increase Individual bouts of nausea, diarrhea and vomiting often pass within a few days, though constipation can stick around much longer

1 2 "Regulation of Sulphur Assimilation Is Essential for Virulence and Affects Iron Homeostasis of the Human-Pathogenic Mould Aspergillus fumigatus"

In fact, some research suggests GIP activation may help buffer some of GLP-1s gut-related side effects