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Although previous ex vivo studies employing NCI-H716 cells (a human L cell line) [35] or human ileal and colonic tissues [14] were indicative of a direct effect of metformin in stimulating GLP-1 release, clinical evidence suggests that the augmentation of postprandial GLP-1 secretion by metformin is largely indirect
Other important risk factors include advanced age (particularly over 65 years), where counter-regulatory hormone responses may be blunted and hypoglycemia awareness reduced
T.PickthornK.BrunsteinF.BlendstrupM.Sanabria BohorquezS.et al
Personalized medical suggestions are always the safest path
For Physicians: Assess & Document Medical Need for Compounded Drugs Physicians, the end of the drug shortage has impacted what you may order from compounding pharmacies
