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The medicinal-chemistry programme that produced cagrilintide, described by Kruse and colleagues in the Journal of Medicinal Chemistry in 2021, addressed this by re-engineering the amylin backbone with structural elements borrowed from calcitonin (a related, non-aggregating peptide) and attaching a fatty-acid side chain that enables reversible binding to serum albumin [1]
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2020 Jan 7;17:3
The clinical consequences of heterogeneity within and between different diabetes types
It is used for similar purposes as GSH, such as antioxidant support and immune system health
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