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A review of anti-obesity treatments found that semaglutide as well as tirzepatide (which has an overlapping mechanism of action) were more promising than previous anti-obesity drugs, although less effective than bariatric surgery

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Diabetes Care 24, 10691078

CrossRef Crocin II alleviates metabolic dysfunction-associated steatotic liver disease by enhancing autophagic degradation of ANGPTL8 Rongtian Zhang, Kongdong Li, Ziting Zhao, Xintong Jiang, Rumeng Zhang, Chang Liu, Wenxiang Zhang, Siyu Chen Targetome .2026;[Epub] CrossRef Endocrine disruptors reprogram hepatic metabolic and immune gene networks to promote hepatocellular carcinoma Yanggang Hong, Yi Wang, Qingyu Chen, Yirong Wang npj Gut and Liver .2026;[Epub] CrossRef Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease Jia-Hui Zhang, Kang Chen, Xiao-Min Zhu, Huan Zhou, Jia-Mi Jiang, Yu-Qing Zou, Ke-Rong Liu, Le Zhang, Yun Li World Journal of Gastroenterology .2026;[Epub] CrossRef Multimodal assessment of hepatic steatosis heterogeneity: segmental MRI-PDFF and ultrasound attenuation coefficient measurement M.M

This shift compresses the gap between your resting rate and your maximum heart rate, effectively narrowing your usable training zones