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Hosseini, E., et al
These agents activate the cAMP-PKA signaling cascade in pancreatic -cells 6 , resulting in glucose-dependent insulin secretion, suppression of pancreatic -cell glucagon release, and modulation of gastrointestinal motility through delayed gastric emptying 7
Further, GLP-1RAs block the adhesion of monocytes to endothelium induced by oxidized LDL via extracellular signal-regulated kinase (ERK) 5-Kruppel-like factor (KLF)2 signaling pathway to prevent endothelial permeability [107, 108]
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