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According to the gut-liver axis theory, the effects of T4 could play an important role in the treatment of NAFLD

It means the peptide remains bioactive and available to cell receptors for a much, much longer period

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PPAR agonists also downregulate glutathione (GSH) levels, increasing reactive oxygen species (ROS) levels, and downregulating retinoic acid receptor-related orphan receptor t (RORt) expression, which facilitates amelioration of Th17-cell-associated immune dysregulation ( Figure 2 ) (52)