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GLP-1s also have an impact on cardiovascular plaque, endothelial repair, and heart failure treatment, independent of their impact on weight

In rare cases, overdose has been associated with acute pancreatitis, a life-threatening inflammation of the pancreas requiring emergency hospitalization

NICE guidance does not mandate preference for daily versus weekly formulations but recommends individualising treatment choice based on patient factors including: Lifestyle and convenience : Weekly injections may suit busy schedules Tolerability : Some patients experience fewer gastrointestinal side effects with certain formulations Clinical efficacy : Specific medications may provide better glucose control or weight loss for individual patients Cost-effectiveness : NHS formularies may influence availability Your GP or diabetes specialist nurse will discuss which dosing schedule best suits your circumstances, taking into account your treatment goals and personal preferences

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The extracellular matrix as a multitasking player in disease