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Asian Pac J Trop Med
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Alidoost et al
therefore, platelet activation is tightly regulated by inhibitory and regulatory receptors that act as endogenous checkpoints, helping to prevent inappropriate activation and maintain hemostatic balance ( 2+ mobilization and integrin activation, inhibitory receptors act by mechanisms such as cyclic nucleotide elevation (cAMP, and cGMP) and immunoreceptor tyrosine-based inhibition motif (ITIM)-mediated phosphatase recruitment to suppress pro-aggregatory signaling (Scridon, 2022)
Microbiota and its metabolites are another important factor affected by oxidative stress, and they are also potential pathways for HT to improve oxidative stress [41]
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