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Reapply after heavy sweating or direct water contact to maintain full SPF 60 efficacy

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Many studies have found that reflux does not directly damage the esophageal epithelium, but stimulates the secretion of inflammatory chemokines by the epithelial cells, which induces proliferative changes in the epithelium and recruitment of inflammatory cells such as T lymphocytes, which in turn leads to the damage of the esophageal epithelium

Raun, K., et al