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Individuals with elevated fasting insulin (suggesting insulin resistance) may see slower initial weight loss because GLP-1 receptor signaling must first improve insulin sensitivity before maximal appetite suppression
However, a long list of factors among them poor sleep, chronic stress and ultra-processed foods act to suppress your natural GLP-1 production and function, making it harder for your body to regulate weight on its own
The effect was statistically significant (P = 0.002), and benefits appeared within just 3-6 months of starting medication
If the device completed normally and there was no obvious leakage, the dose may still have been delivered under the skin
Each approaches GLP-1 support differently, and understanding these alternatives helps contextualize where Pendulum sits in the broader market
