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Collagen peptides from discarded cowhide, exhibiting the highest DPP-IV inhibitory activity (IC50 of 3.04 0.13 mg/mL), were obtained through double enzymatic hydrolysis (papain and compound protease) combined with optimized ultrasound-assisted ionic liquids pretreatment, which exposed active sites, enhanced hydrophobic amino acids, and improved gastrointestinal stability [75]
PMC5217336 Casarini L et al
Pharmacological modulation of the kynurenine pathway, particularly by enhancing KYNA production, could exert profound effects on neurochemical balance and central nervous system function
Ikizler TA, Burrowes JD, Byham-Gray LD, Campbell KL, Carrero JJ, Chan W, et al
BPC-157 steps in like a biological firefighter, calming inflammation at the source
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