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In the eye, Sosne et al., Exp Eye Res 2001 reported accelerated corneal re-epithelialisation and reduced inflammation after injury, and in the central nervous system Xiong et al., J Neurosurg 2012 found that T4 initiated six hours after experimental traumatic brain injury improved sensorimotor and spatial-learning recovery while enhancing hippocampal neurogenesis
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The preclinical data creates false confidence that may not translate to humans
It activates several overlapping pathways, notably VEGFR2 and nitric oxide synthesis via the Akt-eNOS axis, promoting angiogenesis, fibroblast activity, and neuromuscular stabilization
is essential for mitochondrial energy production, DNA repair, and numerous enzymatic reactions, researchers have investigated how modulation of NNMT activity may influence cellular bioenergetics and metabolic efficiency
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